Lon蛋白酶介导的氧敏感性线粒体CBS积累

来源 :中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会 | 被引量 : 0次 | 上传用户：lmh_leo

【摘要】

：

目的:胱硫醚β-合成酶(CBS)作为哺乳动物体内核编码蛋白,含有血红素辅基,是半胱氨酸代谢和硫化氢(H2S)生成的关键酶.线粒体中CBS蛋白水平与线粒体功能关系目前不清,本课题旨在研究线粒体中CBS/H2S水平与线粒体功能关系.方法:Western blotting检测常氧和缺氧状态下线粒体中CBS蛋白水平.基因过表达和基因沉默技术分析CBS蛋白稳定性调节机制.线粒体离体孵育技术检测CBS/H2S

【作者】

：

滕华健吴博赵克新杨广东吴凌云王睿

【机构】

：

湖首大学生理学系,加拿大安大略省桑德贝市P7B 5E1 湖首大学生理学系,加拿大安大略省桑德贝市P

【出处】

：

中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会

【发表日期】

：

2014年3期

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Lon蛋白酶介导的氧敏感性线粒体CBS积累

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