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Individualized medicine is to choose the best therapeutic strategy based on patients genotype.With known genotype, it can choose the proper drug and dosage at the proper time for patients, improve drug efficacy, decline side effects, and decrease suffering and cost simultaneously.Human genetic polymorphisms cause individual difference of drug efficacy and toxicity.It also lead to many new drugs are withdrawn from the market because of the serious toxicity in the genetic mutation carriers.Statistical analysis shows that about 1/3 patients can not get satisfactory efficacy in vast majority drugs, almost 1/6 have side effect in different degrees, and the total effective rate is only about 50%.Up to date, adverse reaction is the fifth leading cause.According to development in genomic research, more and more relationships between genotype and drugs are discovered.It means revolution of drug use is approaching.Individualized medicine therapy can direct drug use in clinical, such as which drug should be used, and predict the efficacy, toxicity and prognostic.These are all based on genotypes and information of the drug related genes.For instance, we use the genotype of HER2 gene to determine whether Herceptin is appropriate for the patients.