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The inflammatory cytokines play a major role in osteoclastogenesis and lead to the bone resorption that is frequently associated with osteoporosis.Ipriflavone has been reported possessed anti-inflammatory activity.The ipriflavone analogues were synthesized and investigated the anti-osteoclastogenesis activity.The series of compounds was subjected to inhibit nuclear factor kappa B ligand (RANKL) plus macrophage colony stimulating factor0induced osteoclatic differentiation from bone marrow stromal cells and RAW264.7 macrophage cells.The ipriflavone analogues,7-fluoroisoflavnoes,were shown benefited bone health by attenuating bone loss through inhibiting the osteoclast.