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A major progress in our understanding of the jasmonate signaling is that the perception of the active hormone by the E3 ubiquitin ligase SCFCOI1 is tightly linked to genome-wide transcriptional reprogramming that is regulated by the master transcription factor MYC2.However,it remains unclear how the jasmonate receptor transmits regulatory information to RNA polymerase Ⅱ to specifically transcribe jasmonate-responsive genes.Here we report that the MED25 subunit of the Arabidopsis Mediator provides an interface for interactions of COI1,MYC2 and the histone acetyltransferase HAC1 at the core promoters of MYC2 targets.Our results unravel a mechanism of how Mediator channels hormone-specific regulatory signals to the Pol Ⅱ general transcription machinery and highlight the ability of Mediator in coordinating gene expression programs of diverse signaling pathways.