Genomewide association study and weighted gene coexpresion network analysis identify novel genetic l

来源 :中国药理学会北美分会药理学学术大会 | 被引量 : 0次 | 上传用户：cheng1129

【摘要】

：

Genetic variants in the pharmacokinetic(PK)mechanism are the main underlying factors affecting the anti-platelet response to clopidogrel.

【作者】

：

Wan-ping ZHONG Hong WU Ji-yan CHEN Xin-xin LI Hao-ming LIN BinZHANG Zhi-wei ZHANG Dun-liang MA Shuo SUN Han-ping LI Li-ping MAI Guo-dong HE Xi-pei WANG He-ping LEI Huang-kai ZHOU Lan TANG Shu-wenLIU S

【机构】

：

Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular In

【出处】

：

中国药理学会北美分会药理学学术大会

【发表日期】

：

2017年10期

【关键词】

：

clopidogrel pharmacokinetics antiplatelet effects genome-wide association study

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Genetic variants in the pharmacokinetic(PK)mechanism are the main underlying factors affecting the anti-platelet response to clopidogrel.

其他文献

Carbon monoxide enhances glucose-stimulated insulin secretion by activating PLC signal pathway in db

Pancreatic β-cells played an important role in glucose homeostatic control.In diabetes,insulin secretion from pancreatic β-cells was increased to deal with theelevated blood glucose.

会议

DEC1 promotes osteogenesis:an involvement of PI3K/Akt/GSK3β/β-catenin signaling pathway

In this study,we confirm that glucocorticoid disturbs osteogenic differentiation characterized by the declined alkaline phosphatase activity,the decreased alkaline phosphatase staining intensities,the

会议

differentiated embryonic chondrocyte expressed gene 1 (DEC1)glucocorticoidicar

Study on pharmacodynamics of QiHu preparation for diabetes

To examine effects of the QiHu preparation for diabetes(QiHu)on reduction of blood glucose levels and protection of organ injures caused by diabetes.

会议

diabetesQiHu preparation for diabeteshyperglycemiahyperlipidemia

Neuroprotective KATP channels and the cerebrovascular risk of sulfonylureas in the treatment of type

Diabetes mellitus(DM) and stroke are leading causes of death and disability.Diabetes and hyperglycemia increase stroke risk significantly,therefore strict glycemic control is a top priority.

会议

Pharmaceutical care for a patient with mediastinitis treated by vancomycin based on population pharm

To explore the pharmacy practice that clinical pharmacists carry out vancomycin individual treatment based on vancomycin population pharmacokinetics and therapeutic drug monitoring in order to expand

会议

clinical pharmacistpopulation pharmacokineticsmediastinitisvancomycintherape

Mass spectrometric multi-reaction simultaneous monitoring of acrolein-deoxynucleoside adduts and its

The exposure to genotoxic chemicals and the occurrence of reactive electrophiles formed in endogenous cellular processes can induce chemical modifications of DNA(DNA adducts or adductomics)and thus tr

会议

DNA adductomicsacroleinmultiple reaction monitoringuntargeted profilingleuko

Determination of the structure and activation mechanism of the human angiotensin II receptor AT1 by

Structures of G-protein coupled receptors are mostly determined by protein X-ray crystallography.Most such receptors need important stabilization efforts either by using stabilizing protein inserts an

会议

Targeting transverse tubular structure in skeletal muscle physiology and diseases

Transverse tubule(TT)networks are critical structures for excitation contraction coupling in striated muscles.Mitsugumin 29(MG29)is a muscle-specific member of the synaptophysin family protein that pa

会议

transverse tubulemicroRNAsmuscular dystrophyMitsugumin29SYPL2

Association of the genetic polymorphism of HLA with the the onset and prognosis of Anaphylactoid Pur

Anaphylactoid Purpura/Henoch-Schonlein Purpura(HSP),the most usual systematic disease in childhood,is a systemic vasculitis with the small vessel vasculitis as the main pathological change.In clinical

会议

genetic polymorphismanaphylactoid purpuraHenoch-Schonlein Purpura nephritis

Effects of tetramethylpyrazine on regeneration of cochlear hair cells after gentamicin poisoning

This study aimed to observe the effects of tetramethylpyrazine on the regeneration of cochlear hair cells exposed to gentamicin by auditory brainstem response test under scanning electron microscope.

会议

tetramethylpyrazinegentamicinscanning electron microscopycochlea

Genomewide association study and weighted gene coexpresion network analysis identify novel genetic l

其他学术论文