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Objective To discuss the preventive methods of hepatitis Bvirus reinfection after liver transplantation.Methods 227 liver transplantation recipients with HBV —related end — stage liver diseases including chronic fulminant hepatitis B,endstage livercirrhosis and liver cirrhosis Merger liver carcinoma were analyzed retrospectively,and were given lamivudine pretransplantation to prevent hepatitis B virus reinfection.