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目的:研究同型半胱氨酸(Hcy)与低踝臂指数(ABI)老年高血压的关系。方法:选取215例老年高血压患者,根据ABI检测值分为正常ABI组(0.90-1.39)108例和低ABI组(<0.90)107例,分别检测体重指数(BMI)、血压(BP)、总胆固醇(TC)、低密度脂蛋白(LDL-C)、Hcy、C反应蛋白(CRP)。结果:2组的年龄、性别、BMI、BP、TC、LDL-C差别无统计学意义(P>0.05);低ABI组的ABI值较正常ABI组明显降低,差别有统计学意义(P<0.05);低ABI组Hcy、CRP值较正常ABI组明显升高,差别有统计学意义(P<0.05);Hcy、CRP与ABI呈负相关(P<0.05)。结论:Hcy与低踝臂指数老年高血压密切相关,高Hcy血症是心血管疾病的重要危险因素,可能参与了老年高血压患者动脉粥样硬化的发生发展,具有重要的临床意义。
Objective: To study the relationship between homocysteine (Hcy) and ankle brachial index (ABI) in elderly hypertensive patients. Methods: A total of 215 elderly hypertensive patients were selected and divided into two groups according to the ABI test value: 108 cases in normal ABI group (0.90-1.39), 107 cases in low ABI group (<0.90), and the levels of body mass index (BMI), blood pressure (BP) Total cholesterol (TC), low density lipoprotein (LDL-C), Hcy, C-reactive protein (CRP). Results: There was no significant difference in age, sex, BMI, BP, TC and LDL-C between the two groups (P> 0.05). The ABI of the low ABI group was significantly lower than that of the normal ABI group (P < 0.05). Hcy and CRP levels in low ABI group were significantly higher than those in normal ABI group (P <0.05). Hcy and CRP were negatively correlated with ABI (P <0.05). Conclusions: Hcy is closely related to the ankle-brachial index hypertension in elderly. Hyperhomocysteinemia is an important risk factor of cardiovascular disease and may be involved in the development of atherosclerosis in elderly hypertensive patients. It is of important clinical significance.