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Aim: To investigate the effect of compatibility of Astragalosides (AST) with Panax Notoginseng Saponins (PNS) on the expression of matrix metalloproteinases-9(MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) after cerebral ischemia reperfusion (CIR) injury in mice and probe its anti-ischemic brain injury protection mechanism.