每周1次度拉糖肽在特殊人群中的药代动力学特点

来源 :中华医学会糖尿病学分会第十八次全国学术会议 | 被引量 : 0次 | 上传用户:wenqianwq
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目的 度拉糖肽(Dulaglutide)是每周1次皮下给药的长效胰高血糖素样肽1(GLP-1)受体激动剂.为度拉糖肽广泛用于2型糖尿病(T2DM)人群提供证据,对其在肝功能或肾功能不全受试者中的药代动力学(PK)特征进行研究.方法 进行了两项独立的单剂量开放研究,比较度拉糖肽1.5 mg在肝功能不全(n=15)或肾功能不全(n=32)受试者中,相对于健康受试者(n=11和n=16)的PK特征.两项研究均纳入了轻度、中度和重度功能不全的受试者,肾功能不全组研究中还纳入了终末期肾病患者.
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