PEI MODIFIED BIODEGRADABLE COMPLEX NANOSPHERES AS GENE TRANSFER VECTOR FOR PROLIFERATION OF ECS

来源 :The 6th International Symposium on Polymer Chemistry(2014年第六 | 被引量 : 0次 | 上传用户：achm207

【摘要】

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【作者】

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Juan Lv Xuefang Hao Jing Yang Yakai Feng

【机构】

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School of Chemical Engineering and Technology,Tianjin University,Weijin Road 92,Tianjin 300072,China

【出处】

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The 6th International Symposium on Polymer Chemistry(2014年第六

【发表日期】

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2014年6期

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Gene therapy is an attractive alternative to realize rapid endothelialization of artificial vascular grafts in current clinical treatments of coronary bypass surgery.Polyethyleneimine (PEI),as nonviral gene carrier,has been widely used to deliver plasmid DNA or siRNA,reaching transfection efficiencies similar to viral vectors1.It is commonly believed that PEI with high molecular weight has perfect transfection efficiencies but increased cytotoxicity2,while low molecular weight PEI has been demonstrated a low toxicity3 but its transfection efficiencies need to improve.

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PEI MODIFIED BIODEGRADABLE COMPLEX NANOSPHERES AS GENE TRANSFER VECTOR FOR PROLIFERATION OF ECS

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