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Objective: To find out whether previous control of the adrenal vein is a crucial procedure in laparoscopic adrenalectomy for pheochromocytoma.Method: From January 2000 to December 2010, 114 pheochromocytoma patients underwent laparoscopic adrenalectomy through transperitoneal or retroperitoneal approach.All the 114 patients were divided into two groups randomly (group 1, dissection after ligation;group 2, dissection before ligation).Blood samples to dose catecholamines using high performance liquid chromatography were carried out at the following times:t1: test just before anesthesia;t2: during manipulationextraction of pheochromocytoma;t3: after removal of pheochromocytoma.The blood pressure fluctuation was recorded.