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The bio-refinery from cheap biomass attracts much attention and endeavor,which is mainly focused on the improvement of strains and fermentation.Down-stream processing for bio-based chemicals becomes bottle-neck in industrial production because so many impurities are introduced into the fermentation broths.Here we summerized salting-out extraction (SOE) based on the partition difference of chemicals in two phases consisting of salts and polymer or hydrophilic solvent,hydrophobic solvent,amphipathic chemicals.The effects of solvents and salts on the formation of two phases were introduced as well as its application in the recovery of bio-based chemicals,such as 1,3-propanediol,2,3-butanediol,acetoin,lactic acid.The diols such as 1,3-propanediol and 2,3-butanediol could be recovered at a yield above 95%,and the recovery of lactic acid also reached 90%,especially from fermentation broths without pretreatment.At the same time,most of the impurities (cells and proteins) were removed in the same step ext