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  5. A modular approach toward multifunctional supramolecular nanopolyplexes for targeting gene delivery

A modular approach toward multifunctional supramolecular nanopolyplexes for targeting gene delivery

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：along365
【摘 要】
：
Gene therapy is a promising approach to treat various human genetic and acquired diseases.Extensive efforts have been explored to increase gene transfection efficiency and low toxicity through rationa
【作 者】
：
Jia Liu Xulin Jiang Wim E.Hennink Renxi Zhuo 
【机 构】
：
Key Laboratory of Biomedical Polymers of Ministry of Education and Department of Chemistry,Wuhan Uni
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
gene therapy cationic polymeric gene vectors multi-functionalization host-guest 
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　　Gene therapy is a promising approach to treat various human genetic and acquired diseases.Extensive efforts have been explored to increase gene transfection efficiency and low toxicity through rational design of degradable and multifunctional polymeric vectors overcoming various transfection barriers.However,it is very challenging to generate a multifunetional polymer conjugates with all rationally designed components.Our strategy is to construct a modular approach to form the supramolecular self-assembly of beta-cyclodextrin-based polymer (PBCD) and many monoadamantane-terminated functionalized polymers via host-gnest interaction for complexing plasmid DNA or siRNA into nanoparticles (Scheme 1).
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