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Mesoporous nanoparticles,which possess highly ordered narrowly distributed nanopores,have already gained enormous attentions in catalysis,separation and sample treatment.Mesoporous nanoparticles with predetermined selectivity or/and desired geometry and kinetic properties hold great promise as sorbents for selective sample enrichment and media for high-efficiency separation.To this end,design and preparation of mesoporous nanoparticles with desired structure and properties is a key.