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Nitric oxide (NO) has attracted lots of attention for its antitumor activity and synergistic effects when co-delivered with anticancer agents [1].However,due to its chemical instability and short halflife,delivering gaseous NO directly to tumors is challenging,let alone co-delivery of NO and antitumor drug into tumor tissue simultaneously.To solve this problem,a novel anti-cancer mixed micelle was prepared here by using D-a-tocopherol polyethylene glycol succinate (TPGS) based redox-sensitive paclitaxel prodrug (TPGS-S-S-PTX) and nitric oxide (NO) releasing TPGS derivative (TNO3).