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After Casimir Effects prediction In 1948 and some years later when experimental measure ments were consistent with the theory, its widespread application were manifested in different parts of physics fields.Physicists demonstrated that Casimir force effected Micromachines structures.Hence, it also must be considered in designing and manufacturing applied physics apparatus.Likewise, the Casimir Effect has its own application in cosmology and theoretical physics which has been mentioned in different articles.In this work through a new approach, Casimir Effect has been probed.in other words, by means of field quantization in Krein space instead of Hilbert space, one can reach to the accurate calculated answer of Casimir force without being involved with infinities which is known by natural quantization.