GABAB receptor-mediated PI3K/Akt signaling protects neurons from apoptosis via transactivation of IG

• 作 者: HaijunTu[1]ChanjuanXu[1]WenhuaZhang[1]QluyaoLiu[1]PhilippeRondard[2]Jean-PhilippePin[2]JianfengLiu[1]
• 机 构: Sino-France Laboratory for Drug Screening, Key Laboratory of Molecular Biophysics (Huazhong Universi
• 出 处: 第二届全国“跨学科蛋白质研究”学术讨论会
• 发表日期: 2008年期

　　γ-amidobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervous system and mediates fast synaptic inhibition through GABAA and GABAC ionotropic receptors as well as slow and prolonged synaptic inhibition through the metabotropic GABAB receptors.GABAB receptors mediate both presynaptic inhibition of neurotransmitter release and post-synaptic inhibition of neuronal excitability.