【摘 要】
：
Since the discovery of dopamine as a chemical neurotransmitter in the brain, many human neurological disorders have been linked to the malfunction of this i
【机 构】
：
Deaprtment of Biopharmaceutical Sciences, Programs in Human Genetics and Biological Sciences Univers
【出 处】
：
2005 WHTS'3rd Annual Congress of International Drug Disc
论文部分内容阅读
Since the discovery of dopamine as a chemical neurotransmitter in the brain, many human neurological disorders have been linked to the malfunction of this important neural system.For example, Parkinsons disease is caused by the selective degeneration of dopamine neurons in the substantia nigra, and dopamine system is strongly implicated in the development of drug and alcohol addiction.The mechanisms underlying dopamine neuron development, regeneration,degeneration, and function are not well understood, and as a consequence, effective treatments for the related human disorders are largely lacking.In this talk, we will discuss our use of a simple vertebrate model system, the zebrafish Danio rerio, to study mechanisms underlying dopamine neuron development, degeneration, and to develop cellular and behavioral assays for functional gene discovery and small molecule screening.
其他文献
目的:探讨α-硫辛酸联合依帕司他治疗糖尿病周围神经病变的临床有效率分析.方法:采用分组对照法进行研究,随机选择2019年1月-2019年12月间于我院接受治疗的62名糖尿病周围神
The Industrial Pharmacy Lab (IPL) is focusing on research in process technology and pharmaceutical drug formulation.This research is very close to the today
目的:探究循证护理在心肌梗死患者并发心力衰竭护理中的应用.方法:选取2019年2月至2020年2月在我院接受治疗的心肌梗死并发心力衰竭患者,符合课题研究标准的病例共58例,通过
目的:分析氟保护漆结合窝沟封闭剂对儿童龋齿预防效果.方法:选择6-7岁的54例儿童为对象,将其随机分组,分别是对照组和研究组,分别实施的是常规口腔护理和氟保护漆结合窝沟封
Dye-tagged proteins including the Green Fluorescent Protein (GFP) and its analogues comprise a rapidly growing arsenal of gene-and structure-based optical p
目的:讨论优质护理服务在老年性脑梗塞护理中的应用效果.方法:将我院神经内科2018年3月至2019年3月收治102例老年性脑梗塞患者当作观察对象,根据护理方式差异分组各51例,对照
Dipeptidyl peptidase Ⅳ (DPPIV; also known as CD26) is a serine protease and expressed ubiquitous as a homodimer on the cell surface of a variety of tissues
目的:分析布地奈德福莫特罗吸入治疗对慢阻肺合并肺癌稳定期的效果.方法:选择2017年1月至2019年12月期间慢性阻塞性肺疾病合并肺癌患者80例作为该次研究对象,利用电脑抽签方
Takotsubo综合征（TTS）是由心理或生理应激所诱发，以可逆性左心功能不全为主要表现的一组临床症候群。TTS临床过程表现各异，最初被认为是一种良性疾病，但现在认为其与左心室流出道
The dominant current paradigm of drug discovery identifies potentially useful targets through one of a number of mics platform technologies.The target under