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目的:严重创伤/休克病人常出现不同程度的血管低反应性,这种血管低反应性的发生严重影响着休克的发生、发展以及治疗,是休克后期血压难以回升和导致死亡的重要原因之一。本实验室前期研究表明在休克后血管低反应性的发生机制中,钙失敏具有重要的作用。同时,还发现应用药物预处
Objective: Severe traumatic / shock patients often have varying degrees of vascular hyporesponsiveness, the occurrence of vascular hyporesponsiveness seriously affect the occurrence of shock, development and treatment, is one of the important reasons for post-shock blood pressure is difficult to rise and lead to death . Previous studies in our laboratory showed that calcium desensitization plays an important role in the pathogenesis of vascular hyporesponsiveness after shock. At the same time, also found that the application of drug pre-treatment