【摘 要】
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The BRAF mutation is the most common genetic alteration in papillary thyroid cancer (PTC).An activating mutation of BRAFV600E has been found in 36% t0 6g% o
【机 构】
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Departments of Thyroid and Neck Tumor1,Tianjin Medical University Cancer Institute and Hospital,Onco
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The BRAF mutation is the most common genetic alteration in papillary thyroid cancer (PTC).An activating mutation of BRAFV600E has been found in 36% t0 6g% of patients with PTC.This mutation is very prevalent in PTC and is frequent in the tumors in late stages (stages Ⅲ and Ⅳ) of PTC,with lymphovascular,invasion and metastases.However,other studies did not find any association between BRAFV600E mutation and tumor stage,local invasiveness and lymph node metastasis.In our study,we found that 51.2 PTC have BEAFV600E mutation and in patients with multiple PTC,the status of lymph node metastasis was related to the earlyage at diagnosis,the larger tumor,extra-thyroidal invasion,and BRAFV600E mutation status.We also found that highly aggressive tumors may arise in a significant subset of patients with BRAFV600E mutation and tumour size<5 mm.Extrathyroidal invasion,lymph node metastases,and the type of surgical procedures were significantly associated with recurrence.
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