【摘 要】
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Objective To study the effect of enriched environment (EE) on post-stroke cognitive impairment (PSCI) and EE on the epigenetic regulation of cholinergic circuits.Methods First we established a phototh
【机 构】
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Department of Neurological rehabilitation, Affiliated WuTaiShan Hospital of Yangzhou University, Yan
【出 处】
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中华医学会第十六次全国物理医学与康复学学术会议
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Objective To study the effect of enriched environment (EE) on post-stroke cognitive impairment (PSCI) and EE on the epigenetic regulation of cholinergic circuits.Methods First we established a photothrombotic mouse PSCI model, then mice with PSCI and sham-operated mice were randomly divided into 4 groups: sham-operated mice in Standard Environment (SHAM+SE), sham-operated mice 1in Enriched Environment (SHAM+EE), PSCI mice in Standard Environment (PSCI+SE) and PSCI mice in Enriched Environment (PSCI+EE).Each group had 25 qualified mice.SHAM+SE and PSCI+SE mice were housed in regular cages (30 cm long × 19 cm wide × 13 cm high) whereas the enriched mice were in more spacious cages (60 cm long × 36 cm wide × 28 cm high) equipped with rodent toys of various shapes, colors and an exercise running wheel.Toys were changed twice a week during bedding changes and mice were kept under EE for at least 4 weeks before behavioral testing and molecular biological testing.
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