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To investigate the relationship between Akt signaling pathway and the protective effects of ischemic postconditioning (IP) after focal cerebral ischemia reperfusion, male adult Kunming mice were randomly divided into five groups: sham-surgery, ischemia/reperfusion (I/R), LY294002, IP and IP plus LY294002 groups.Models of right middle cerebral artery occlusion (MCAO) were established.