【摘 要】
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The organic cation/camitine transporter (OCTN2) is a high affinity cation/carnitine transporter widely expressed in human tissues, including skeletal muscle
【机 构】
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Shenyang Pharmaceutical University, Shenyang 110016, China
【出 处】
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2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
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The organic cation/camitine transporter (OCTN2) is a high affinity cation/carnitine transporter widely expressed in human tissues, including skeletal muscle,kidney, brain, heart,and placenta.OCTN2 is essential for L-camitine transport in humans[1]Mutatious of the OCTN2 gene in humans cause primary systemic camitine deficiency, with clinically significant symptoms that include hypoketotic hypoglyce mia,cardiomyopathy, and skeletal myopathy.[2,3] Use of OCTN2 transporter as a target to change the pharmacokinetic properties of drug in the body is a new bright spot in the field of oral drug delivery.
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