【摘 要】
：
Older age is the major risk factor for cardiovascular diseases, which is, in part, attributable to dysfunctional arteries.Large elastic artery stiffness, on
【机 构】
：
University of Kentucky,Kentucky,USA
【出 处】
：
2014 International Conference on Aging and Disease(2014年第一届衰
论文部分内容阅读
Older age is the major risk factor for cardiovascular diseases, which is, in part, attributable to dysfunctional arteries.Large elastic artery stiffness, one expression of arterial dysfunction, is worsened with aging and is an independent predictor of cardiovascular events.Both oxidative stress and inflammation within the artery are important signaling pathways in the development of age-related arterial stiffening.Recent evidence, however, has also shown a causal role for periaortic adipose-related oxidative stress and inflammatory signaling to promote arterial stiffness with aging.Importantly, translational nutraceutical and functional food interventions may de-stiffen arteries that, in turn, reduce cardiovascular risk in older adults by ameliorating oxidative stress and inflammation.
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