Mouse models in cardiovascular disease research

来源 :The 11th transgenic Technology Meeting ISTT2013 ( 第十一届国际转基因技 | 被引量 : 0次 | 上传用户：taotao_xr

【摘要】

：

SIRT1 has been reported to mediate the effects in extending life span of CR in lower organisms.To investigate the effect of SIRT1 on cardiovascular system, a se

【作者】

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De-pei Liu

【机构】

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StateKeyLaboratoryofMedicalMolecularBiology,InstituteofBasicMedicalSciences;ChineseAcademyofMedicalS

【出处】

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The 11th transgenic Technology Meeting ISTT2013 ( 第十一届国际转基因技

【发表日期】

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2013年2期

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SIRT1 has been reported to mediate the effects in extending life span of CR in lower organisms.To investigate the effect of SIRT1 on cardiovascular system, a series of specific SIRT1 transgene mice were generated.Firstly, high fat diet on ApoE KO mice is a classical AS mouse model.As the first barrier of vessel wall, endothelium plays important role in pathogenesis of AS.

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Mouse models in cardiovascular disease research

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