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The cocrystals and salts of an anti-hepatitis b drug, adefovir dipivoxil (AD), were synthesized to improve its stability, which were AD gallic acid cocrystal (1) ,AD salicylic acid salt (2), AD maleic acid salt (3), respectively.The structures of 1-3 were determined by the single crystal X-diffraction and the samplers prepared by suspension methods , as well as ball-milling methods.The complexes show advantages in terms of stability in comparing to pure AD.The results of the stability for AD and its complexes with their mixtures, under three different conditions, were show great improvement especially in harsh conditions such as in high temperature and methanol ambient.According to the DVS, the complexes were not water absorption comparing to the API for the hydrogen bonding sites have been saturated, which were also supposed to the reason of the improvement of the stability of the complexes.