Intravenous Vitamin C as a Cell-Signalling Molecule in Sepsis

• 作 者: IanDettman;
• 机 构: Biological Therapies Melbourne Australia
• 出 处: BIT`s 2nd Annual World Congress of Endobolism-2012(2012第二届内分
• 发表日期: 2012年期

　　Vitamin C is a versatile molecule which has roles in cell signalling far beyond the traditional view of its requirement as a vitamin.A promising area of research is emerging where an understanding is developing of the effects of pharmacological concentrations of vitamin C on many of the signalling pathways involved in septic shock.Both in vitro and pre-clinical studies have shown a dramatic reduction in the progression and severity of sepsis signalling responses when vitamin C is introduced in sufficient amounts.The levels required for clinically meaningful effect can be achieved in animals and humans with intravenous administration of high doses;the doses required have been used commonly in human clinical practice when treating other conditions.This session will present a review of the current understanding of how vitamin C controls sepsis signalling and some of the pre-clinical research that supports this.