Wnt/β-catenin Pathway Forms a Negative Feedback Loop during TGF-β1 Induced Human Normal Skin Fibrobl

• 作 者: JiaqiLiu[1]YunchuanWang[1]QingPan[2]ZhanfengZhang[1]JuntaoHan[1]XiongxiangZhu[1]ChaowuTang[1]DahaiHua[1]
• 机 构: Department of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University,
• 出 处: 第八届全国创伤修复(愈合)与组织再生学术交流会
• 发表日期: 2012年期

　　Background Fibroblast-to-myofibroblast transition is a key event during wound healing and hypertrophic scar formation.Previous studies suggested Wnt/β-catenin signaling might be involved in the wound healing.However,its specific role in skin fibroblast-to-myofibroblast transition remains unclear.Objective To investigate the specific role of β-catenin during the transforming growth factor-β1 induced normal skin myofibroblast transition.