Anticoagulants and anti-platelet agents are simultaneously administrated in clinical practice(i.e.percutaneous coronary intervention),which cause significant risk of systemic bleeding.Targeted deliver
Fatty actci biosynthesis is essential for bacterial survival.FabH,β-ketoacyl-acyl carrier protein(ACP)synthase Ⅲ,is a particularly attractive target,since it is central to the initiation of fatty acid
Series of novel Schiffs base derivatives have been synthesized by combining 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl 4-formylbenzoate 5,6 with aromatic/heterocyclic amine 7a-r,8,9a-r in ethanol.All
A series of aryl-2H-pyrazole derivatives were synthesized and evaluated for inhibitory activity against xanthine oxidase in vitro as potent xanthine oxidase inhibitors.Among them,2 aryl-2H-pyrazole de
A series of 1-methyl-1H-indole-pyrazoline hybrids were designed,synthesized,and biologically evaluated as potential tubulin polymerization inhibitors.Among them,compound e19 [5-(5-bromo-1-methyl-1H-in
A series of novel compounds(6a-6v)containing l-methylindol and 31-(4,5-dihydro-lH-pyraxol-1-yl)ethanone skeleton were designed,synthesized and biologically evaluated as potential tubulin polymerizatio
A series of novel compounds(8a-21b)were designed and synthesized based on lH-benzo[d]imidazole.Their biological activities were evaluated as potential tubulin polymerization inhibitors and anticancer
Microtubule-targeted drugs are at present indispensable for various types of cancer therapy worldwide.A series of chalcone oxime derivatives were designed,synthesized and evaluated as potential tubuli
A series of novel quinazoline derivatives have been designed and synthesized,and their inhibitory activities have also been tested against A549(carcinomic human alveolar basal epithelial cell),MCF-7(b