【摘 要】
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INTRODUCTION Skeletal muscle is a heterogeneous and highly complex tissue having multiple functions in the vertebrate body.During embryonic development,transcription factors Myf5,Mrf4,and MyoD are res
【机 构】
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State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guan
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INTRODUCTION Skeletal muscle is a heterogeneous and highly complex tissue having multiple functions in the vertebrate body.During embryonic development,transcription factors Myf5,Mrf4,and MyoD are responsible for the specification of progenitor cells to become muscle lineage-committed myoblasts,whereas Myogenin,MyoD,and Mrf4 regulate the differentiation of myoblasts.Even though transcription regulation is the key process in muscle differentiation,the procedure of fusion and elongation of myoblasts to form myofibers is also controlled by a multitude of membrane and cytosolic proteins.Palmdelphin is a predominant cytosolic isoform of the Paralemmin family,which are lipid raft-associated proteins implicated in plasma membrane dynamics and cell shape control.Palmdelphin was expressed in variable abundances in nearly all tissues,with highest expression in the heart and lung.
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