Differential subcellular distribution of beta1-and beta2-Adrenoceptors in the rat basolateral nucleu

• 作 者: Nan-NanGUO;Bao-MingLI;
• 机 构: Laboratory of Higher Brain Functions, Institute of Neurobiology, Fudan University, Shanghai 200032,
• 出 处: 中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
• 发表日期: 2007年期

　　beta-Adrenoceptors (ARs) in the basolateral nucleus of amygdala (BLA) play an essential role in regulating synaptic plasticity and fear memory.However,little is known about the cellular and subcellular distributions of beta-ARs in this brain structure.Here,we reported that betal-and beta2-ARs are predominantly expressed in neurons but not in astrocytes in the BLA.Interestingly,betal-AR is predominantly distributed in the cell membrane and cytoplasm of neurons,whereas beta2-AR not only in the membrane and cytoplasm but also in the karyon.This differential subcellular distribution of betal-and beta2-ARs may have different functional significance in leaming and memory.