论文部分内容阅读
TAK1-NLK cascade is an authentic inhibitory pathway to canonical Wnt signaling through phosphorylating and ubiquitylating LEF-1/TCFs family transcription factors.In this work, we found TAB2 (TAK1 Binding protein 2) directly interacts with NLK and mediate the interaction between TAK1 and NLK.In a NLK stable-expressed 293 cells, TAKI-TAB2 could be co-immnoprecipitated with NLK, and knocking down TAB2 using siRNA abolished endogenous TAK1-NLK interaction.