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Percutaneous ablation is the currently preferred locoregional therapy for non-resectable hepatocellular cancer (HCC).Cryoablation is an attractive option because it forms an ice ball viewable by many imaging methods.This study assessed the therapeutic effect of comprehensive cryoablation (of intra-and extrahepatic tumors) in patients with metastatic HCC.Forty-five patients met the inclusion criteria from January,2004 to October, 2011.