Rehabilitation after injury or stroke is a long process towards regaining function and independence.Changes exhibited in these areas tend to be subtle and highly dependent on several variables.We util
Propargylic alcohols are versatile synthetic intermediates in modern organic synthesis.
Indole and its derivatives are important scaffolds in natural products and pharmaceuticals[1].
Imidazole and its derivatives are an important class of heterocyclic compounds due to their prevalence in bioactive natural products and drugs.
7-Thia-2.3-diazaspiro[4.4]-non-3-en-1-one framework derivatives are present in a number of natural and pharmaceutical products,such as important brain protective agent.
芳基腈是一类重要的有机合成中间体,因为它们可以简单有效的转化为各种重要官能团,例如:羧酸、脒、胺类以及吡唑、苯三唑、四唑等杂环化合物.本文以铜为催化剂,DMF 作为唯一氰源,成功实现了碘代芳烃、溴代芳烃、富电子芳烃以及芳基醛的氰基化.
噻吩并噻吩及其稠合化合物在医药、农药、导电聚合物、笼形晶体、有机导体和超导体、感光受体、光电子材料、染料等方面有广泛的应用[1].目前,合成噻吩并噻吩并嘧啶酮类化合物的方法主要有以下三种:1)以含有异氰基噻吩衍生物为原料经分子内的环化缩合[2].
烯酮亚胺是应用于有机合成的重要反应中间体,常以CuAAC( Copper-catalyzedalkyne-azide cycloaddition)策略制备[1],以亲核试剂捕获,能高效构筑不同结构的杂环化合物[2].将该合成策略应用于分子内反应,可制备一系列环状化合物[3].
The delivery of a small-molecule agent into malignant tumors in a highly effective and highly selective way is a major challenge in successful chemotherapeutic intervention in cancer[1-3].
芳酰基甲酸是重要的有机合成中间体,广泛应用于药物、功能材料和精细有机化学品的合成等领域[1],近年来芳基甲酰甲酸作为一类新型的芳酰基化试剂引起了广泛关注.芳甲酰甲酸的普遍方法是利用高锰酸钾氧化苯乙酮类化合物来制备,但该方法高锰酸钾消耗量较大,易产生副产物和工业废水,同时后处理也较为繁琐,因此采用副产物少而且易于后处理的氧化体系来制备芳酰基甲酸化合物具有重要研究意义.