BRCT Domain Containing Protein ECT2 Is an Essential Regulator in DNA Repair and Genome Integrity

• 作 者: Cheng Cao Nan Song Lei Shi
• 机 构: Tianjin Medical University
• 出 处: 2019中国肿瘤学大会
• 发表日期: 2019年7期
• 关键词: ECT2 DNA damage BRCT

　　Objective Defects of DNA damage response(DDR)will result in genome instability and drive carcinogenesis.Proteins carrying BRCA1 C Terminus(BRCT)domains have evolved to response and resolve DNA damage.However,it remains unknown that whether BRCT domain containing protein Epithelial cell transforming sequence 2(ECT2)plays a role in DDR.