【摘 要】
：
脂氧合酶(LOXs)是炎症相关疾病的重要靶标,而现有LOXs酶活测试方法的不足,减缓了靶向LOXs的抗炎药物研发进程.我们利用LOXs代谢产物脂质过氧化物的氧化能力建立了基于荧光染料DHR和基于FTC复合物的LOXs酶活测试新方法,期望为靶向LOXs的抗炎先导化合物开发奠定基础.
【机 构】
：
华东理工大学药学院,上海市新药设计重点实验室 上海市梅陇路130号,200237
论文部分内容阅读
脂氧合酶(LOXs)是炎症相关疾病的重要靶标,而现有LOXs酶活测试方法的不足,减缓了靶向LOXs的抗炎药物研发进程.我们利用LOXs代谢产物脂质过氧化物的氧化能力建立了基于荧光染料DHR和基于FTC复合物的LOXs酶活测试新方法,期望为靶向LOXs的抗炎先导化合物开发奠定基础.
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