DL0805衍生物对肺动脉血管细胞的作用及机制研究

来源 :2016第十一届心血管药理专业委员会全国心脑血管药理学术会议 | 被引量 : 0次 | 上传用户：sczr2898

【摘要】

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【作者】

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袁天翊张惠芳陈俞材焦晓臻谢平方莲花杜冠华

【机构】

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药物靶点研究与新药筛选北京市重点实验室,中国医学科学院&北京协和医学院药物研究所活性物质发现与适

【出处】

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2016第十一届心血管药理专业委员会全国心脑血管药理学术会议

【发表日期】

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2016年11期

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目的:肺动脉高压(Pulmonary artery hypertension,PAH)是以肺动脉压力进行性升高,进而导致右心衰竭为特征的高致死率疾病.目前针对这一疾病已有多种治疗药物应用于临床,但它们主要是通过舒张肺动脉血管来发挥作用,对于肺动脉血管病变未表现出明显治疗作用.因此,目前PAH的治疗药物没有显著提高PAH患者生存率,不能满足临床需求.发现新的、对肺动脉血管病变具有治疗作用的化合物对于这一疾病的治疗具有重要意义.基于该背景,本实验旨在研究两个新结构Rho激酶(Rho-associated coiled-coil forming protein serine/threonine kinase,ROCK)抑制剂DL0805衍生物(DL0805-1、DL0805-2)在肺动脉血管细胞上的保护作用及其机制,评价其成为抗PAH药物的可能性.

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DL0805衍生物对肺动脉血管细胞的作用及机制研究

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