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Glutathione conjugation and transportation of glutathione conjugates of anticancer drugs out of cells are important for detoxification of many anticancer drugs.Inhibition of this detoxification system has recently been proposed as a strategy to treat drug-resistant solid tumors.Gallbladder carcinoma is resistant to many anticancer drugs, therefore, it is needed to develop a novel strategy for cancer therapy.In the present study, we tested the effect of emodin (1,3,8-trihydroxy-6-methylanthraquinone), a reactive oxygen species (ROS) generator reported by our group previously, in combination with cisplatin(CDDP), carboplatin (CBP) or oxaliplatin in treating the gallbladder carcinoma cell line SGC996.