【摘 要】
：
Wilms tumor protein (WT1) is widely expressed in hematologic malignancies and regarded as a leukemic antigen with potential importance.However,the immunogenicity of WT1 antigen is usually weak and nee
【机 构】
：
Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing,China 100005
【出 处】
：
中国微米纳米技术学会纳米科学技术分会第三届年会暨2014全国纳米生物与医学学术会议
论文部分内容阅读
Wilms tumor protein (WT1) is widely expressed in hematologic malignancies and regarded as a leukemic antigen with potential importance.However,the immunogenicity of WT1 antigen is usually weak and needs further improvement with immune-modulating techniques.In this study,we investigated whether WT1 peptide co-encapsulated with CpG in poly(lactide-co-glycolide) (PLGA) microparticles (MPs) would enhance the anti-leukemic immunity mediated by human dendritic cells (DCs).
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