【摘 要】
：
Objective: To investigate the relationship between 18F-fluoro-2-deoxy-glucose (18F-FDG) uptake of primary lesions and epidermal growth factor receptor(EGFR) mutations in patients with non-small cell l
【机 构】
：
Department of Nuclear Medicine,Sun Yat-sen University Cancer Center,Guangzhou,510060,China
【出 处】
：
The 1st Sino-American Conference on Nuclear Medicine(首届中美核医学
论文部分内容阅读
Objective: To investigate the relationship between 18F-fluoro-2-deoxy-glucose (18F-FDG) uptake of primary lesions and epidermal growth factor receptor(EGFR) mutations in patients with non-small cell lung cancer (NSCLC) and the feasibility of EGFR mutations predicted by the maximum standard uptake value(SUVmax).Methods: Totally 66 patients dated from Nov.2006 to Sept.2010, who underwent PET / CT examination and EGFR mutation analysis before any anti-tumor therapies, then we did retrospective analysis and research.The 18F-FDG uptake of the primary lesions was described with SUVmax and the EGFR mutation status in exons 19 and 21 were detected by fluorescent quantitative PCR method.Results: The EGFR mutation rate was 33% in exons 19 and 21.The SUVmax in EGFR mutant type was lower than wild type (9.8±4.8, 13.9 ± 5.5,P=0.006).The SUVmax and EGFR mutations were performed as a negative correlation (r =-0.344, P =0.005).For the prediction of EGFR mutations using SUVmax, the area under the receiver operating characteristic curve (AUC) was 0.71(P =0.006), when chose 8.8 as cut-off value, the Youden Index reached a maximum value of 0.43.And also the EGFR mutation was more likely to occur in the patients with SUVmax lower than 8.8 (P=0.000).The SUVmax was still a statistically significant predicter for EGFR mutations in multi-factor logistic regression (P =0.007).Conclusion: The 18F-FDG uptake of primary lesions in NSCLC patients was negatively correlated with EGFR mutations; patients with lower SUVmax were more likely to harbor EGFR mutations.For the NSCLC patient, it might be helpful to identify who is suitable to tyrosine kinase inhibitors (TKI).
其他文献
Objective: Cystine-knot peptides, like Agouti-related protein(AgRP) and Ecballium elaterium trypsin inhibitor(EETI), provided a rigid structural framework that enabled us to engineer peptide mutants w
Objective:The present study was to investigate salivary iodine kinetics and dosimetry in repeated courses of radioiodine (131I) therapy for diffcrentiated thyroid cancer (DTC) for better understanding
Objective: Annexin V, a human protein with a high affinity for phosphatidylserine (PS), has been labeled to detect apoptosis in vivo.Vascular endothelial groth factor (VEGF) plays a pivotal role in tu
Objective: To investigate the feasibility of monitoring stem cells using baculovirus vectors for the delivery of the sodium-iodide symporter (NIS) gene as a reporter.Methods: Induced pluripotent stem
Objective: The application of monoclonal antibodies targeting biomarkers expressed on tumor cells for imaging plays a pivotal role in the early detection and prognosis of cancer.3H11 is a monoclonal a
Objective: The limited resolution of PET imaging induces partial volume effects (PVE).The PVE makes the image quality impair.The aim of the study is to investigate the PVE and its influence factors fo
Objective 131I plays an important role in the treatment of differentiated thyroid carcinoma (DTC) and its metastasis, 131I therapy was chosen at first for DTC patients with cervical lymphatic metastas
Objective: To investigate and compare the feasibility of rat sodium iodide symporter (rNIS) and human NIS (hNIS) as reporter genes for noninvasive monitoring of rat bone marrow mesenchymal stem cells
Objective: Evaluation of nasopharyngeal carcinoma (NPC) using 18F-FDG PET/CT is limited due to artifact from the intense physiologic uptake of 18F-FDG in the brain.We attempted to improve detection of