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  5. The Correlation Between hMLH1 Methylation and Clinicopathological Characteristics in Chinese Gastric

The Correlation Between hMLH1 Methylation and Clinicopathological Characteristics in Chinese Gastric

来源 :第十三届全国胃癌学术会议 | 被引量 : 0次 | 上传用户：QQ2009sunboy
【摘 要】
：
Objective Functional inactivation of MMR genes,such as human mutL homolog 1(hMLH1),by promoter methylation is responsible for the MSI-high(MSI-H)phenotype in gastric cancer.MLH1 gene methylation have
【作 者】
：
Qing Wei Qiong He Qi Xu Jingjing Li Lei Chen Cong Luo Ying Jieer 
【机 构】
：
Zhejiang Cancer Hospital
【出 处】
：
第十三届全国胃癌学术会议
【发表日期】
：
2018年3期
【关键词】
：
Methylation Gastric Cancer MLH1 
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　　Objective Functional inactivation of MMR genes,such as human mutL homolog 1(hMLH1),by promoter methylation is responsible for the MSI-high(MSI-H)phenotype in gastric cancer.MLH1 gene methylation have been shown to play pivotal roles in gastric cancer pathogenesis,the significance of this event on clinicopathological feathures and survival outcomes in patients with gastric cancer remains unknown.
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