论文部分内容阅读
Purpose:In mammalian genetic models of aging,it has been known that a genetic deletion of the p66-Shc gene extends life span at least by 30％ in mice,partly due to an increased resistance to oxidative stress.Shc is a phosphotyrosine-specific signal adapter protein,which triggers the first signaling step following the activation of the so-called receptor tyrosine kinases (RTKs).