Early repeated AMD3100 administration dose-dependently improves neuropathic pain in rats after L5 sp

来源 :The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会) | 被引量 : 0次 | 上传用户：liuyc077

【摘要】

：

Multiple lines of evidence suggest that AMD3100 has analgesic effects on many pathological pain states, including peripheral neuropathic pain.However, little is known about the underlying mechanisms.

【作者】

：

Fang Xie Xueyang Li Mengmeng Bao Ruijuan Guo Chen Zhang Anshi Wu Yun Guan Yun Wang Yun Yue

【机构】

：

Department of Anesthesiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, 100020

【出处】

：

The 6th Asian Pain Symposium, APS 2015(第六届亚洲疼痛研讨会)

【发表日期】

：

2015年9期

【关键词】

：

neuropathic pain AMD3100 analgesic effect opioid

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

　　Multiple lines of evidence suggest that AMD3100 has analgesic effects on many pathological pain states, including peripheral neuropathic pain.However, little is known about the underlying mechanisms.

其他文献

REDOX AND ZINC-DEPENDENT MODULATION OF T-TYPE CA2+ CHANNELS IN SENSORY NEURONS CONTRIBUTES TO PERIPH

Neuropeptide substance P (SP) is both produced and released by a subset of peripheral sensory neurons that respond to tissue damage (nociceptors);these neurons also express SP receptors (NK1-3).SP exe

会议

Mechanisms underlying the peripheral sensitization of bone cancer pain

Bone cancer pain resulting from primary tumors or tumors that metastasize to bone is one of the most severe and intractable types of cancer pain, which reduces the quality of the cancer patients life.

会议

Bone cancer painPeripheral sensitizationKCNQ/M (Kv7)potassium channelP2X3 rec

Up-regulation of belta4 subunit of large-conductance Ca2+-activated potassium channels in the anteri

The large-conductance Ca2+-and voltage-gated K+ channels or BK channels are ubiquitously expressed throughout the central nervous system including the cingulate cortex and contribute to action potenti

会议

FXYD2, a γ subunit of Na+,K+-ATPase, maintains persistent mechanical allodynia induced by inflammati

Objective Na+,K+-ATPase (NKA) is required to generate the resting membrane potential in neurons.Our previous study showed that activation of NKA in dorsal root ganglin (DRG) neurons by follistatin-lik

会议

FXYD2Na+K+-ATPaseinflammatory paindorsal root ganglion

Involvement of Mitochondrial Uncoupling Protein 4 in Chronic Pain via Alleviating Mitochondrial Dysf

Mitochondria are the most important organelles in neurons with essential functions, yet very little research has addressed on its potential role in pain.

会议

UCP4mitochondrial dysfunctionchronic pain

Astrocyte-derived CXCL12 Promotes Pain Hypersensitivity through CXCR4-mediated Neuroinflammation in

Mitogen-activated protein kinases (MAPK)-mediated chemokine-cytokine networks in glial cells are likely involved in the pathological process of spinal central sensitization, the basic mechanism underl

会议

ChemokineAstrocytesMicrogliaMitogen-activated Protein KinasesNeuroinflammati

Fibroblast growth factor 7 is a nociceptive modulator secreted via large dense-core vesicles

Objective Fibroblast growth factor (FGF) 7, a member of FGF family, is initially found to be secreted from mesenchymal cells to repair epithelial tissues.However, its functions in the nervous system a

会议

FGF7DRGLDCVnociceptive modulatorinflammatory pain

Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice

The contributions of gasotransmitters to itch sensation are largely unknown.In this study, we aimed to investigate the roles of hydrogen sulfide (H2S), a ubiquitous gasotransmitter, in itch signaling.

会议

H2SitchpainCav3.2 T-type calcium channelTRPA1TRPV1

Inhibition of cystathionine β-synthetase desensitizes sodium channel activities of dorsal root gangl

Background: The pathogenesis of pain in lumber disc herniation (LDH) remains poorly understood.We have previously reported that voltage-gated sodium channels (VGSCs) in dorsal root ganglion (DRG) neur

会议

Lumbar disc herniationDorsal root ganglionVoltage-gated sodium channelsPainH

Cellular Distribution of Marker Genes in Distinct Types and Subtypes of Somatosensory Neurons

Somatosensory neurons in the dorsal root ganglia (DRG) detect various stimuli and relay the information to postsynaptic neurons in the spinal dorsal horn.DRG neurons are traditionally classified into

会议

Somatosensory neurondorsal root gangliain situ hybridizationrepresentative ge

Early repeated AMD3100 administration dose-dependently improves neuropathic pain in rats after L5 sp

其他学术论文