NAD辅酶及其类似物与脱氢酶相互作用研究

来源 :第八届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：zxtx001209

【摘要】

：

烟酰胺腺嘌呤二核苷酸(NAD)是生物体内重要的辅酶,与其依赖的脱氢酶结合并行使催化功能时,通常以烟酰胺单核苷酸(NMN)朝向酶活性口袋内,腺嘌呤核苷酸(AMP)朝外的伸展状态形成复合物,反应过程经历结合、氢传递和解离过程.NAD与脱氢酶的结合力包括氢键、范德华力、疏水作用等,是其在生物体内参与众多生物化学反应的作用基础.

【作者】

：

刘武军张祎昕王磊王雪颖赵宗保

【机构】

：

中科院大连化学物理研究所生物技术部大连市中山路457号,116023

【出处】

：

第八届全国化学生物学学术会议

【发表日期】

：

2013年2期

【关键词】

：

NAD 相互作用等温量热滴定石英晶体微天平

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NAD辅酶及其类似物与脱氢酶相互作用研究

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