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Objective Hypomyelination is the major cause of neurodevelopmental deficits that are associated with perinatal white matter injury.Chondroitin sulfate proteoglycans (CSPGs) are known to exert inhibitory effects on the migration and differentiation of oligodendrocytes (OLs).However, few studies describe the roles of CSPGs on myelination by OLs and the cognitive dysfunction (CD) that follows perinatal white matter injury.Here, we examined the alterations in the expression of CSPGs and their functional impact on the maturation of OLs and myelination in a neonatal rat model of hypoxicischemic (HI) brain injury.