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Purpose:Vascular endothelial growth factor (VEGF) has been implicated to play a major role in the RVO.Our aim is to evaluate efficacy of intravitreal bevacizumab(IVB) and intravitreal ranibizumab(IVR) for macular edema in Retinal Vein Occlusion(CRVO and BRVO).Methods:We searched MEDLINE,Embase,and the Cochrane Library systematically with no limitations of language.Quality was assessed by two independent researchers.