ACTX,A MARINE ACTINOMYCIN,AS A POTENT APOPTOSIS INDUCER WITH ANTICANCER ACTIVITY THROUGH SUPPRESSING

• 作 者: XunZhu[1]JuehengWu[1]ZhenjianHe[1]JiahuiPan[2]JunLi[1]YongchengLin[2]JieYuan[1]MengfengLi[1]
• 机 构: Key Laboratory of Tropical Disease Control(Sun Yat-sen University)Ministry of Education,Guangzhou,Ch
• 出 处: 15th International Symposiium on the Biology of Actinomycete
• 发表日期: 2009年期

　　The aims of this study were to investigate the anti-cancer activity in vitro and in vivo of actinomycin X (ActX),an actinomycin D analog isolated from a strain of Streptomyces antibioticus from a marine sediment and furthermore to explore its underlying molecular mechanisms.In MTT assay.ActX could dramatically suppress the growth of the solid human tumor cell lines in a time-and dose-dependent manner.