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The currently employed multiple-step process for drying down preparative HPLC fractions to a dry powder ready for use or storage can be inefficient,laborious and suffers from several bottlenecks preventing higher throughput.The relatively large fraction volumes with high aqueous content frequently require long cycle times to recover the dried powder.In addition,anything not sufficiently volatile/evaporable in the mobile phase will concentrate down with the sample leading to a loss of mass purity,especially water and common mobile phase additives such as formic acid and TFA.Accumulation of additives in the dried sample can lead to "weighing errors," which will propagate into the preparation of a known-concentration solution.In addition,HPLC additives,both chemically bound with a compound or as an unbound excess,may be unfavourable in further activity testing.In this paper we will describe the development of a new instrumentation platform designed to process preparative HPLC fractions to high purity dry powders,free from HPLC background and available in as few as three hours after the HPLC run,regardless of fraction volume or water content.