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1.Historical background In the 1920th, Otto Warburg conducted a series of research showing that different kinds of tumor cells produced lactic acid from glucose by "fermentation" even in the presence of adequate oxygen[1], which is less efficient to produce ATP than oxidative phosphorylation.Warburg did not use the term "aerobic glycolysis" at that time for this metabolic process, but later it was called so by other research groups as well as by Warburg himself[2-3].