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Objective: Teratospermia seriously affect male infertility.The production of abnormal sperm is closely related to the process of the sperm spermiagenesis, but the molecular mechanism is uncovered.Design: In our study, DNA sequencing was used to find the potential mutant on the genome and then the expression of the interested genes were identified by immunofluorescence.Materials and methods: Seven male with decapitated sperm and 100 normal were inclusion in this study.DNA isolated from the blood and the whole exons of the SPATA6 and Hook1, both of which are associated genes found in defect mouse, were sequenced in human.